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I work as a medicinal chemist looking at new medicines that could be used to treat a range of different diseases. The biologists give an idea of the protein we want our medicine to interact with. X-ray crystal structures of our compounds give us pictures of the protein. These let us design changes to the chemical structure that will make a better shaped structure to inhibit that enzyme. This is like designing a better shaped key to try to unlock a door. Once we draw on paper the chemical structure we want to make, then we have to work out how to make it. This can be the most difficult part! Sometimes it can take many reactions, and many weeks, before we are successful. When we finally make the compound, it is a really good feeling, especially if it took a long time.

We give the compound to biologists, who tell us if it interacts well with the protein – a good shaped key to unlock the door! This is a test in a small tube, with cells, or blood from people who donate it in our blood donation unit. Eventually, and after many attempts to get the compound correct, we might test it in an animal. We have very strict rules about when we can do this, and the types of experiments we can do. It is also very expensive, so we have to make sure we have the best possible compound. Eventually – if the project is successful – we hope to get a license that allows us to start clinical trials and see if our medicine works in patients. That really would be great!

In the morning, I get in and check my email. If I have had a chemical reaction going overnight, I look to see if it has worked. If it has worked, that is a good start to the morning! I spend some time in the lab – I have to purify my reaction next. This means getting rid of all the things in the mixture that I don’t want, so that in the end what I have is very pure and clean. I check in with my team members. I talk to them about any problems they have with their own chemistry, and we work out how they might be able to solve them. My team has a real mixture of experience – we have people who have worked as chemists for 30 years, and we have students doing a one year placement at GSK as part of their degree.

After lunch, I look at any results that our biologists have from their experiments on the compounds we made. Then I think about what new compounds we could make, and what chemical reactions we need to do to make them. Sometimes we go to lectures about chemistry, where we learn new things that are going on in universities or other companies.